Synthesis of Milbemycins .ALPHA.9, .ALPHA.10, .ALPHA.11, .ALPHA.12, .ALPHA.14, .ALPHA.15, .ALPHA.20, .ALPHA.21, .ALPHA.22, .ALPHA.23, .ALPHA.26, .ALPHA.27, .DELTA.2,3,.DELTA.4,26-Milbemycins A3, A4 from Milbemycins A3, A4, and Their Acaricidal Activities.
نویسندگان
چکیده
منابع مشابه
Microbial conversion of milbemycins: microbial conversion of milbemycins A4 and A3 by Streptomyces libani.
28-hydroxymilbemycins, 1 3/?,30-dihydroxymilbemycins, and others.4~8) On the other hand, Ramos Tomboet al. have reported 13/Miydroxylation and 14, 1 5-epoxidation of milbemycins by Streptomyces violascens ATCC31560.9) During our screening of microbial conversion of milbemycin A4 (la), we observed that an actinomycete, strain SANK65087, newly isolated from soil, converted milbemycin A4 (la) to a...
متن کاملMicrobial conversion of milbemycins: 13 beta, 29-dihydroxylation of milbemycins by soil isolate Streptomyces cavourensis.
Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broadspectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A3 (2b), A4 (lb), and D (3b) from milbemycins A3 (2a), A4 (la), and D (3a), respectively, and 1 3j...
متن کاملMicrobial conversion of milbemycins: 28-hydroxylation of milbemycins by Amycolata autotrophica.
Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broad-spectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A4, A3, D, 13/Miydroxy-LLF28249a, 28-hydroxymilbemycin D, and 28-hydroxy-LL-F28249a by using Cunn...
متن کاملMicrobial conversion of milbemycins: hydroxylation of milbemycin A4 and related compounds by Cunninghamella echinulata ATCC 9244.
Many strains of zygomycetes and actinomycetes were found to convert milbemycin A4 (1a) to 13 beta-hydroxymilbemycin A4 (1b). Among these strains, Cunninghamella echinulata ATCC 9244 had the most efficient 13 beta-hydroxylation ability on milbemycins. In the conversion of milbemycin A3 (2a), 29-hydroxymilbemycin A4 (4a), and 30-hydroxymilbemycin A4 (5a) with this strain, only 13 beta-hydroxylate...
متن کاملEngineered biosynthesis of milbemycins in the avermectin high-producing strain Streptomyces avermitilis
BACKGROUND Milbemycins, produced from Streptomyces hygroscopicus subsp. aureolacrimosus and Streptomyces bingchenggensis, are 16-membered macrolides that share structural similarity with avermectin produced from Streptomyces avermitilis. Milbemycins possess strong acaricidal, insecticidal, and anthelmintic activities but low toxicity. Due to the high commercial value of the milbemycins and incr...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2002
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.55.993